KEGG   Homo sapiens (human): 25885
Entry
25885             CDS       T01001                                 
Symbol
POLR1A, A190, AFDCIN, HLD27, RPA1, RPA190, RPA194, RPO1-4, RPO14
Name
(RefSeq) RNA polymerase I subunit A
  KO
K02999  DNA-directed RNA polymerase I subunit RPA1 [EC:2.7.7.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03020  RNA polymerase
Disease
H00679  Hypomyelinating leukodystrophy
H01376  Acrofacial dysostosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03020 RNA polymerase
    25885 (POLR1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    25885 (POLR1A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.6  DNA-directed RNA polymerase
     25885 (POLR1A)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase I system
   RNA polymerase I
    Core subunits
     25885 (POLR1A)
SSDB
Motif
Pfam: RNA_pol_Rpb1_5 RNA_pol_Rpb1_2 RNA_pol_Rpb1_3 RNA_pol_Rpb1_1 RNA_pol_Rpb1_4 NOA36
Other DBs
NCBI-GeneID: 25885
NCBI-ProteinID: NP_056240
OMIM: 616404
HGNC: 17264
Ensembl: ENSG00000068654
UniProt: O95602
Structure
Position
2:complement(86020216..86105886)
AA seq 1720 aa
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR
NT seq 5163 nt   +upstreamnt  +downstreamnt
atgttgatctccaagaacatgccctggcggcggctgcagggcatttccttcgggatgtat
tcggctgaagagctcaagaaattaagtgttaaatccattacgaaccctcgatacctggac
agcctggggaacccatcggcaaacggcctgtacgatttagctttgggccctgcagattcc
aaagaggtgtgctccacctgcgtgcaggacttcagcaactgttctgggcacctgggccac
attgagctcccactcacagtgtataaccctctcctcttcgataagctgtacctgctgctt
cggggctcttgtttaaactgccacatgctgacttgtccccgggccgtgattcacctctta
ctctgccagctgagggttctggaagtcggggccctacaagcagtctacgagcttgagaga
attctgaacaggtttctggaagaaaatcccgatccctctgcctctgaaattcgggaggaa
ttagaacaatacacaactgaaattgtgcagaacaacctcctggggtcccagggcgcacat
gtaaagaacgtgtgtgagagcaagagcaagctcattgctctcttctggaaggcacatatg
aatgctaagcgctgtccccactgcaagaccgggcgatccgttgtccgaaaggaacacaac
agcaagttgactatcacgtttccagccatggtgcacaggacagctggccagaaggactct
gagcccctgggaattgaggaagctcagataggaaaacgaggatacttaacacccaccagt
gcccgcgaacacctttctgccctgtggaagaatgaaggattctttctgaactaccttttt
tcgggaatggatgatgatggtatggaatccagattcaatcccagtgtgttctttctagat
ttcttggtggtgccgccctcaaggtatcgcccagtcagtcgcctaggagaccagatgttt
actaatggccagacggtgaacttgcaggctgtcatgaaggatgtagttctgattcgaaaa
cttctggcattgatggcccaagaacagaagttgccagaggaagtggccacacccactaca
gatgaggaaaaagactctttgattgctattgaccgatcctttttgagtacacttccaggc
cagtccctcatagacaaactttacaacatttggattcgccttcagagccacgtcaatatt
gtgtttgatagcgagatggacaaactaatgatggacaagtacccaggcattaggcagatc
ctggagaagaaagaaggcctgttccgaaaacacatgatgggaaagcgagtggactacgct
gcgcgctcagtcatctgcccagacatgtacatcaacaccaacgaaattggaattcccatg
gtgtttgccacaaaactgacctacccacagccagttaccccatggaatgttcaggaactt
aggcaagcggtcatcaacggccctaatgtgcacccaggagcctccatggtcatcaatgag
gacggcagccgcacagccctgagcgctgtggacatgacccagcgagaggccgtggccaag
cagcttctgaccccagccacgggggcacctaagccccaggggacaaaaattgtgtgccgg
catgtgaagaatggggacattctgctactgaaccgacagcccacactgcacagaccctcc
atccaggcccaccgtgcccgcatcctgcctgaagagaaagtgctgcggctccactatgcc
aactgcaaggcctataatgccgactttgatggagacgagatgaatgcccatttcccccag
agtgagctgggccgggccgaggcctacgtcctggcctgcactgatcagcagtaccttgtt
cccaaggatggccaaccattggcgggactgatccaggatcacatggtttcaggggcaagc
atgactactcggggttgctttttcacccgggagcactatatggagctggtgtaccgagga
ctcacggacaaagtggggcgcgtgaagctcctttctccttccatcctgaagccctttccg
ctgtggacaggaaaacaggttgtgtcaacgctgctcataaatataatcccagaggaccac
atcccactgaacttatctggaaaggcgaaaatcactgggaaagcctgggtgaaggaaact
cctcgatccgttcctggctttaaccctgactcgatgtgcgagtcccaggtgatcatcagg
gaaggggagctgctctgcggagtgctggacaaggcgcactatgggagctccgcctacggc
ctggtccactgctgctatgagatctatggaggcgagaccagcggcaaggttctaacctgc
ctggcccgcctcttcaccgcctacctgcagctctacagaggcttcaccttgggcgtggaa
gacattttggtgaagccaaaggcagatgtcaagaggcaacgtatcattgaagaatccacc
cactgcgggccccaggctgtcagggctgcattaaacctgccagaagccgcatcatatgat
gaggtccgaggaaaatggcaggatgcccatctgggcaaggaccagagggattttaacatg
attgatctgaagttcaaggaggaagtgaaccattacagcaatgagattaacaaggcatgc
atgccttttggcctacacagacagttcccagagaacagcctgcagatgatggtgcagtcg
ggagccaaaggttcaactgtgaacacgatgcagatctcgtgcctgctgggccagattgaa
ctggaaggtcggagacccccgctgatggcgtctggcaagtcactgccctgctttgagcct
tatgagttcacccccagggctggtggctttgtcactggcaggttcctcaccggcatcaaa
cctcctgagttcttcttccactgcatggcaggacgagagggcctggtggacactgctgtg
aaaaccagccgctcaggctatctccaaaggtgcatcatcaagcacctagaggggctggtc
gtgcagtatgatctcacggtccgtgacagtgacggcagtgtggtgcagttcctgtatggg
gaggatggcctggacatccccaagacacagttcctgcagcccaagcagttccccttcctg
gccagcaactacgaggtgataatgaaatcacagcatctccatgaagttttatccagagca
gatcccaaaaaagctctccaccacttcagagctatcaaaaaatggcaaagcaagcacccc
aacaccctgctgagaagaggcgccttcttgagttattcccagaaaattcaggaagctgtg
aaagccctgaaacttgagagtgaaaaccgcaatggccgcagccctgggactcaggagatg
ctgaggatgtggtatgagttggatgaggaaagccgaaggaaataccagaagaaggcggcc
gcttgtcctgaccccagtctgtctgtctggcgtcctgacatctactttgcatcagtgtca
gaaacatttgaaacaaaggttgatgactacagtcaagagtgggcagctcaaacagagaag
agttatgagaaatcagagctttctctcgacaggttgaggaccttgctgcagctgaagtgg
cagcgctcactgtgtgagccgggcgaggctgtgggcctgctggctgcccagagcatcgga
gagccctccacccagatgaccctcaacaccttccactttgcaggcagaggcgagatgaac
gtcaccctgggcattccaaggttgcgggagattctcatggtggccagcgccaacatcaag
acacccatgatgagcgtgcccgtgctcaacaccaagaaagccctgaagagagtgaaaagc
ctgaagaagcaactcaccagggtgtgcttgggggaggtgttgcagaaaattgacgtccag
gagtccttctgtatggaagaaaaacagaacaaattccaggtgtaccagctgcggtttcag
ttcctgccacatgcatattaccagcaggagaagtgcctgagacccgaggacatcctgcgc
ttcatggaaacaagattctttaaacttctgatggaatccatcaaaaagaagaataataaa
gcatcagctttcaggaacgtaaacactcgaagagctacacagcgggatctggacaacgct
ggggagttggggaggagtcggggagagcaggagggtgatgaggaagaggaggggcacatt
gtggatgctgaagctgaggagggggacgccgatgcctctgatgccaaacgcaaggagaag
caggaggaggaggttgattatgagagtgaggaagaggaggagagggagggcgaggagaac
gacgatgaagacatgcaggaggaacgaaatccccacagggaaggtgctcgaaagacccaa
gagcaagatgaagaggtgggcttaggcactgaggaggacccgtcccttcccgccctcctg
acgcagccccggaaacccacccacagccaggagccccaggggcccgaggccatggagcgc
cgggtccaggctgtgcgtgagatccacccgttcatagatgactaccagtacgacaccgag
gagagcctgtggtgccaggtgacagtgaagctccctctgatgaagatcaactttgacatg
agctccctggtagtatctttggcccatggtgccgtcatctatgcgaccaagggcatcact
cggtgcctcctgaatgaaacaaccaacaataagaacgagaaggagcttgtgctaaacaca
gaaggaatcaacctcccagagctattcaagtatgcagaggtcctggatctgcgccgcctc
tactccaacgacatccacgccatagccaacacgtatggcattgaggccgcgctgcgggtg
atcgagaaggagatcaaggatgtgtttgccgtgtatggcatcgcggtcgaccctcgccat
ctctccctggttgctgattatatgtgcttcgagggtgtttacaagccactgaatcgcttt
gggatccggtcaaactcttccccgctacagcagatgacatttgaaaccagcttccagttt
ctgaagcaagccaccatgctgggatcccacgatgagctgaggtctccttctgcctgcctt
gtggtcgggaaggtcgtcaggggcgggacaggcctgttcgagctcaagcagcctctgaga
tag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (35)   
   RefSeq(nuc) (1)   
   GenBank (17)   
   EMBL (17)   
3D Structure (7)   
   PDB (7)   
Protein domain (6)   
   Pfam (6)   
All databases (85)   

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